Dapoxetine for Premature Ejaculation: An Updated Meta-Analysis of Randomized Controlled Trials

The set price will be charged at the time of the first test. No additional payment is required for the second and third tests. You can take the second and third tests at a time of your choice. Note that it is valid for a year. For those who purchase the three-session package, we also offer a special discount for PrEP. The price shown in parentheses is the price per dose for a set of three doses.

• Dapoxetine is designed specifically for men with PE.
• Over-the-counter sales increase the risk of misuse.
• Some online platforms may sell banned drugs illegally.
• Personal health history should guide dapoxetine use.
• Pharmacovigilance ensures medication safety.
• Consider counseling along with medication for better results.
• Check expiration date before use.
• Keep medication in a cool, dry place.
• Report any adverse reactions to health authorities.
• Be aware of regional laws regarding dapoxetine sales.

*The results of the discharge test will be explained by the doctor, so a separate consultation fee will apply.

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Vaginitis (vaginal candida and bacterial vaginosis) can be managed with an option focused on preventing recurrence. We also offer prevention of vaginitis through phone consultation and medication delivery. When it recurs four or more times per year, it is referred to as recurrent vaginal candida, and recurrence rates of approximately 60-70% within 6 months have been reported. Using preventive medication for vaginal candida taken once weekly for 6 months has been reported to reduce the recurrence rate to approximately 10-20%. Induction therapy (initial phase): Oral dosing on day 1, day 4 and day 7 (3 doses total) Maintenance therapy (maintenance phase): As a general rule, continue oral dosing once weekly for 6 months After completing 6 months of maintenance therapy, we will monitor progress and consider next steps as needed. Patients who purchase Screening Premium, Screening Premium Plus, Ladies Bridal, or Full Set can add an HPV test at the special prices below.

– HPV Genotyping (Basic): 5,000 JPY (Regular price: 7,000 JPY) – HPV Genotyping (Full): 19,000 JPY (Regular price: 23,000 JPY) We also offer package menus without HIV tests. The prices for STI treatments provided at our clinic are as follows: Currently, the injectable syphilis treatment “Sterelyze® (potassium penicillin G for IV infusion)” is under recall by the manufacturer, Pfizer, due to a formulation issue, and its supply has been temporarily suspended.

• Only a licensed healthcare provider can determine the appropriate treatment.
• Illegally imported dapoxetine may have incorrect storage conditions, affecting potency.
• Some men may experience fainting (syncope) with dapoxetine, requiring caution.
• Official medication guides detail all potential side effects and instructions.
• Stress and anxiety can contribute to PE; addressing these may be beneficial.
• Support groups can provide shared experiences and coping strategies.

Oral medications and testing remain available as usual.

Our clinic offers PrEP at package prices, which include all the necessary blood tests for the use and continuation of PrEP. * First visit: 2,500 JPY, 2nd+ visit: 1,000 JPY Note that PrEP prescription requires doctor’s consulation. Patients who purchase PrEP at our clinic can contact us 24/7 via LINE with any questions about PrEP interactions with other medications, how to take PrEP, and more.

Morning-After Pill (Emergency Contraception)

Always ensure that you undergo appropriate tests when starting and/or continuing PrEP. Prescriptions from facilities that do not conduct various tests, or personal imports without testing, carry the significant risk of HIV resistance and worsening of hepatitis B. – 1 bottle of PrEP (30 tablets), Descovy – Syphilis test (results notified via e-mail) dapoxetine sildenafil online – Renal function test (results notified via e-mail) – 3 bottles of PrEP (90 tablets), Descovy – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) – 6 bottles of PrEP (180 tablets), Descovy – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) – Extra test kit to use 3 months after (HIV, hepatitis B, syphilis and renal function) If you underwent HIV and hepatitis B testing within the past week, we can prescribe PrEP at the prices below. Please bring documentation of your test results. You must undergo appropriate testing before initiating or continuing PrEP.

How long does it take to get a prescription from Hi-Doctor?

Obtaining PrEP from facilities that do not perform the required tests, or through personal imports without testing, carries serious risks including HIV resistance and worsening hepatitis B. Tests conducted outside our clinic also qualify. If you use our three-exam regular package, it already includes HIV and hepatitis B tests, so you may receive your prescription on the day of testing. Available only to those who bring HIV and hepatitis B test results from within the past week – Renal function test (email results): additional 500 JPY upon request Available only to those who bring HIV and hepatitis B test results from within the past week – Renal function test (email results): additional 500 JPY upon request For those who import PrEP on their own, we have a package of routine check-ups. for those importing PrEP on their own – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) Gonorrhea and Chlamydia (genitals, throat, anus): 3,000 JPY (20,000 JPY) Discharge test (vaginal candida, vaginal trichomonas and bacterial vaginosis): 3,000 JPY (4,500 JPY) Contraceptive injection (Depo-Provera): 8,000 JPY* (9,000 JPY) per dose or 22,000 JPY* (25,000 JPY) per 3-dose package *If you purchase PrEP, doxy-PEP or medication for the prevention of vaginal candida from us, we can offer special pricing.

How does premature ejaculation impact a man’s life?

For patients using PrEP who wish to start Doxy-PEP, same-day prescription is available by adding the gonorrhea and chlamydia test (genital, throat and rectal). This option also offers a 2,000 JPY discount compared to the standard price. We offer a comprehensive package that includes mental support for those taking PEP all the way until HIV negativity is confirmed. Depending on the circumstances of the potential exposure, necessary additional tests are also provided within this package at no extra cost. For urgent PEP prescriptions, such as when more than 72 hours have passed since exposure which is beyond the usual consultation hours, please contact us via our official LINE account. Please don’t hesitate to reach out. Always ensure that you undergo appropriate tests when starting and/or continuing PrEP. Prescriptions from facilities that do not conduct various tests, or personal imports without testing, carry the significant risk of HIV resistance and worsening of hepatitis B. – 1 bottle of PrEP (30 tablets), Descovy – Syphilis test (results notified via e-mail) dapoxetine sildenafil online – Renal function test (results notified via e-mail) – 3 bottles of PrEP (90 tablets), Descovy – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) – 6 bottles of PrEP (180 tablets), Descovy – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) – Extra test kit to use 3 months after (HIV, hepatitis B, syphilis and renal function) If you underwent HIV and hepatitis B testing within the past week, we can prescribe PrEP at the prices below. Please bring documentation of your test results.

• In some regions, dapoxetine can be bought OTC legally.
• Beware of scams offering cheap dapoxetine online.
• Combining dapoxetine with alcohol increases side effects.
• Dapoxetine has a quick onset, usually within an hour.
• The drug is taken as needed, not daily.
• OTC availability depends on local medicine laws.
• Self-medicating with dapoxetine can lead to health risks.
• Dapoxetine is designed to improve control over ejaculation.
• Check local regulations before seeking OTC dapoxetine.
• Consult a pharmacist about dapoxetine availability and safety.

You must undergo appropriate testing before initiating or continuing PrEP. Obtaining PrEP from facilities that do not perform the required tests, or through personal imports without testing, carries serious risks including HIV resistance and worsening hepatitis B. Tests conducted outside our clinic also qualify. If you use our three-exam regular package, it already includes HIV and hepatitis B tests, so you may receive your prescription on the day of testing.

Why choose Hi-Doctor over unregulated peptide sellers

[Price] = [Consultation Fee] + [Package Price] + [Optional Fees] – Consultation Fee: First visit 2,500 JPY, Follow-up 1,000 JPY – A doctor’s consultation is required for PrEP prescriptions. – 1 bottle of PEP (30 tablets of Taffic) * Take 1 tablet daily for 28 days. The remaining 2 tablets are for backup use. Special discounted testing for syphilis, gonorrhea, chlamydia, and other STIs is available at dapoxetine 30mg tablet the start and after completing PEP. We offer the following discounted tests exclusively to those who purchase a PEP package, valid for one month from the date of purchase.

J Sex Med

Gonorrhea & Chlamydia (Genital, Throat, Anal – 3 sites): 3,000 JPY (20,000 JPY) Vaginal Discharge Test (Vaginal Candida, Trichomonas, Bacterial Vaginosis): 3,000 JPY (4,500 JPY) These options are valid for one month after purchasing PEP. A follow-up test one month after completing PEP is available at a special discounted price. If you wish to use doxy-PEP in addition to PEP, adding the “Gonorrhea and chlamydia (genital, throat and rectum; 3 sites)” test (3,000 JPY) allows same-day doxy-PEP prescription. We offer gonorrhea, chlamydia and syphilis testing at a special price for everyone who starts or continues doxy-PEP. HIV, Hepatitis B & Kidney function: 3,000 JPY HIV, Hepatitis B, Kidney function & Syphilis: 5,000 JPY This method involves taking medication within 72 hours after sexual activity to prevent syphilis, gonorrhea, and chlamydia.

An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation

The reported effectiveness of prevention is 87% for syphilis, 88% for chlamydia, and 55% for gonorrhea (International AIDS Society, July 2022). These STIs have a high transmission rate when having sexual contact with an infected person—around 30% for syphilis and 50% for chlamydia and gonorrhea—making this prevention method highly effective and globally recognized. We provide thorough explanations of the risks and benefits of preventive medications during a doctor’s consultation and determine eligibility for each patient. Please consult with our doctor for more details. Prescriptions can also be provided through telephone consultations. Available only to those who bring HIV and hepatitis B test results from within the past week – Renal function test (email results): additional 500 JPY upon request Available only to those who bring HIV and hepatitis B test results from within the past week – Renal function test (email results): additional 500 JPY upon request For those who import PrEP on their own, we have a package of routine check-ups.

Rights and permissions

The set price will be charged at the time of the first test. No additional payment is required for the second and third tests. You can take the second and third tests at a time of your choice. Note that it is valid for a year. For those who purchase the three-session package, we also offer a special discount for PrEP.

Value Packages

The price shown in parentheses is the price per dose for a set of three doses. *The results of the discharge test will be explained by the doctor, so a separate consultation fee will apply. Patients who purchase Screening Premium, Screening Premium Plus, Ladies Bridal, or Full Set can add an HPV test at the special prices below. – HPV Genotyping (Basic): 5,000 JPY (Regular price: 7,000 JPY) – HPV Genotyping (Full): 19,000 JPY (Regular price: 23,000 JPY) We also offer package menus without HIV tests. The prices for STI treatments provided at our clinic are as follows: Currently, the injectable syphilis treatment “Sterelyze® (potassium penicillin G for IV infusion)” is under recall by the manufacturer, Pfizer, due to a formulation issue, and its supply has been temporarily suspended.

Ethics approval and consent to participate

Oral medications and testing remain available as usual. Our clinic offers PrEP at package prices, which include all the necessary blood tests for the use and continuation of PrEP. * First visit: 2,500 JPY, 2nd+ visit: 1,000 JPY Note that PrEP prescription requires doctor’s consulation. Patients who purchase PrEP at our clinic can contact us 24/7 via LINE with any questions about PrEP interactions with other medications, how to take PrEP, and more. Please don’t hesitate to reach out. for those importing PrEP on their own – Syphilis test (results notified via e-mail) – Renal function test (results notified via e-mail) Gonorrhea and Chlamydia (genitals, throat, anus): 3,000 JPY (20,000 JPY) Discharge test (vaginal candida, vaginal trichomonas and bacterial vaginosis): 3,000 JPY (4,500 JPY) Contraceptive injection (Depo-Provera): 8,000 JPY* (9,000 JPY) per dose or 22,000 JPY* (25,000 JPY) per 3-dose package *If you purchase PrEP, doxy-PEP or medication for the prevention of vaginal candida from us, we can offer special pricing. For patients using PrEP who wish to start Doxy-PEP, same-day prescription is available by adding the gonorrhea and chlamydia test (genital, throat and rectal). This option also offers a 2,000 JPY discount compared to the standard price. We offer a comprehensive package that includes mental support for those taking PEP all the way until HIV negativity is confirmed. Depending on the circumstances of the potential exposure, necessary additional tests are also provided within this package at no extra cost. For urgent PEP prescriptions, such as when more than 72 hours have passed since exposure which is beyond the usual consultation hours, please contact us via our official LINE account. [Price] = [Consultation Fee] + [Package Price] + [Optional Fees] – Consultation Fee: First visit 2,500 JPY, Follow-up 1,000 JPY – A doctor’s consultation is required for PrEP prescriptions.

Important Safety Notes

In collaboration with the AIDS Clinical Center (ACC) and our partner clinic, Personal Health Clinic based in Tokyo, we prescribe Doxy-PEP to patients at high risk of contracting STIs. We are accumulating data to evaluate the effectiveness of Doxy-PEP in Japan and aim to develop new preventive healthcare models and contribute to society. [Price] = [Consultation Fee] + [Package Price] + [Optional Fees] – Consultation Fee: First visit 2,500 JPY, Follow-up 1,000 JPY – Doxy-PEP prescriptions require a mandatory consultation with a doctor. Before starting or continuing Doxy-PEP, proper testing is essential. Receiving a prescription without testing or through personal imports without examination increases the risk of antimicrobial resistance and is dangerous.

Competing interests

To receive a Doxy-PEP prescription, testing for syphilis, gonorrhea and chlamydia (all potentially exposed sites) is required. We offer special discounted STI testing for everyone starting or continuing Doxy-PEP. Syphilis, gonorrhea and chlamydia (genital, throat and rectum): 5,000 JPY (normally 20,000 JPY) If you prefer individual tests in combination with other services, we offer the following discounted prices: Syphilis (quantitative): 3,000 JPY (normally 5,000 JPY) Gonorrhea and chlamydia (genital, throat and rectum): 3,000 JPY (normally 20,000 JPY) If you have completed testing for syphilis, gonorrhea and tadalafil dapoxetine chlamydia (all potentially exposed sites) within the past week, you can receive a prescription with only a consultation and medication fee. This applies to test results from other clinics as well. If you are using our 3-test regular package, Doxy-PEP can be prescribed on the day of testing, as it includes syphilis, gonorrhea and chlamydia.

Outcome measures

If you are requesting Doxy-PEP as a medication-only option, please bring documentation of your test results. Always undergo proper testing when starting or continuing Doxy-PEP. Prescriptions from clinics that do not offer testing or imported medications without testing are risky and may lead to antimicrobial resistance. We also offer a discounted vaginal discharge test (for vaginal candida, trichomonas and bacterial vaginosis) for those prescribed Doxy-PEP. Vaginal discharge test (vaginal candida, trichomonas, bacterial vaginosis): 3,000 JPY (normally 4,500 JPY) Contraceptive injection (Depo-Provera): 8,000 JPY* (9,000 JPY) per dose or 22,000 JPY* (25,000 JPY) per 3-dose package *If you purchase PrEP, doxy-PEP or medication for the prevention of vaginal candida from us, we can offer special pricing. – 1 bottle of PEP (30 tablets of Taffic) * Take 1 tablet daily for 28 days. The remaining 2 tablets are for backup use. Special discounted testing for syphilis, gonorrhea, chlamydia, and other STIs is available at dapoxetine 30mg tablet the start and after completing PEP. We offer the following discounted tests exclusively to those who purchase a PEP package, valid for one month from the date of purchase.

Gonorrhea & Chlamydia (Genital, Throat, Anal – 3 sites): 3,000 JPY (20,000 JPY) Vaginal Discharge Test (Vaginal Candida, Trichomonas, Bacterial Vaginosis): 3,000 JPY (4,500 JPY) These options are valid for one month after purchasing PEP. A follow-up test one month after completing PEP is available at a special discounted price. If you wish to use doxy-PEP in addition to PEP, adding the “Gonorrhea and chlamydia (genital, throat and rectum; 3 sites)” test (3,000 JPY) allows same-day doxy-PEP prescription. We offer gonorrhea, chlamydia and syphilis testing at a special price for everyone who starts or continues doxy-PEP. HIV, Hepatitis B & Kidney function: 3,000 JPY HIV, Hepatitis B, Kidney function & Syphilis: 5,000 JPY This method involves taking medication within 72 hours after sexual activity to prevent syphilis, gonorrhea, and chlamydia. The reported effectiveness of prevention is 87% for syphilis, 88% for chlamydia, and 55% for gonorrhea (International AIDS Society, July 2022). These STIs have a high transmission rate when having sexual contact with an infected person—around 30% for syphilis and 50% for chlamydia and gonorrhea—making this prevention method highly effective and globally recognized. We provide thorough explanations of the risks and benefits of preventive medications during a doctor’s consultation and determine eligibility for each patient. Please consult with our doctor for more details. Prescriptions can also be provided through telephone consultations. In collaboration with the AIDS Clinical Center (ACC) and our partner clinic, Personal Health Clinic based in Tokyo, we prescribe Doxy-PEP to patients at high risk of contracting STIs. We are accumulating data to evaluate the effectiveness of Doxy-PEP in Japan and aim to develop new preventive healthcare models and contribute to society. [Price] = [Consultation Fee] + [Package Price] + [Optional Fees] – Consultation Fee: First visit 2,500 JPY, Follow-up 1,000 JPY – Doxy-PEP prescriptions require a mandatory consultation with a doctor. Before starting or continuing Doxy-PEP, proper testing is essential.

What Are the Side Effects of Dapoxetine Use?

Receiving a prescription without testing or through personal imports without examination increases the risk of antimicrobial resistance and is dangerous. To receive a Doxy-PEP prescription, testing for syphilis, gonorrhea and chlamydia (all potentially exposed sites) is required. We offer special discounted STI testing for everyone starting or continuing Doxy-PEP. Syphilis, gonorrhea and chlamydia (genital, throat and rectum): 5,000 JPY (normally 20,000 JPY) If you prefer individual tests in combination with other services, we offer the following discounted prices: Syphilis (quantitative): 3,000 JPY (normally 5,000 JPY) Gonorrhea and chlamydia (genital, throat and rectum): 3,000 JPY (normally 20,000 JPY) If you have completed testing for syphilis, gonorrhea and tadalafil dapoxetine chlamydia (all potentially exposed sites) within the past week, you can receive a prescription with only a consultation and medication fee. This applies to test results from other clinics as well. If you are using our 3-test regular package, Doxy-PEP can be prescribed on the day of testing, as it includes syphilis, gonorrhea and chlamydia. If you are requesting Doxy-PEP as a medication-only option, please bring documentation of your test results. Always undergo proper testing when starting or continuing Doxy-PEP. Prescriptions from clinics that do not offer testing or imported medications without testing are risky and may lead to antimicrobial resistance. We also offer a discounted vaginal discharge test (for vaginal candida, trichomonas and bacterial vaginosis) for those prescribed Doxy-PEP.

• Dapoxetine should not be used by men with significant heart or liver problems.
• Unregulated "OTC" sales circumvent these critical safety checks.
• Reputable medical journals publish studies on dapoxetine's efficacy and safety.
• The cost of prescribed dapoxetine varies by insurance and generic availability.
• Behavioral start-stop and squeeze techniques can be learned and practiced.
• Patience is required as treatments may take time to show full effect.

Vaginal discharge test (vaginal candida, trichomonas, bacterial vaginosis): 3,000 JPY (normally 4,500 JPY) Contraceptive injection (Depo-Provera): 8,000 JPY* (9,000 JPY) per dose or 22,000 JPY* (25,000 JPY) per 3-dose package *If you purchase PrEP, doxy-PEP or medication for the prevention of vaginal candida from us, we can offer special pricing. Vaginitis (vaginal candida and bacterial vaginosis) can be managed with an option focused on preventing recurrence. We also offer prevention of vaginitis through phone consultation and medication delivery. When it recurs four or more times per year, it is referred to as recurrent vaginal candida, and recurrence rates of approximately 60-70% within 6 months have been reported.

Using preventive medication for vaginal candida taken once weekly for 6 months has been reported to reduce the recurrence rate to approximately 10-20%. Induction therapy (initial phase): Oral dosing on day 1, day 4 and day 7 (3 doses total) Maintenance therapy (maintenance phase): As a general rule, continue oral dosing once weekly for 6 months After completing 6 months of maintenance therapy, we will monitor progress and consider next steps as needed.