Priligy 15 mg for First-Time Users

Tell your doctor if you use recreational drugs such as ecstasy, LSD, narcotics, or benzodiazepines. Tell your doctor if you have or have had any medical conditions, especially the following: • History of dizziness from low blood pressure • Heart and blood vessel problems • Bleeding tendencies • Depression • Psychiatric disease, such as schizophrenia • History of mania (great excitement, hallucinations, difficulty in concentrating or staying still) or bipolar disorder (extreme mood swings) or develop these disorders • Seizures (fits) or have uncontrolled epilepsy • Severe liver or kidney problems • Eye disorders such as raised intraocular pressure (raised pressure in the eye that can lead to blindness) or angle-closure glaucoma (high pressure in the eye that can lead to blindness) Taking other medicines: PRILIGY might interact with other medicines. Tell your doctor if you are taking any other medicines, including medicines you can buy without a prescription from a pharmacy, supermarket or health food shop. • Medicines to thin your blood, such as warfarin (Coumadin®, Marevan®), or medicines that can cause bleeding, such as non-steroidal anti- inflammatory medicines like ibuprofen (Nuorfen®)and aspirin (Disprin®). • Certain medicine used to treat high blood pressure and chest pain (angina), enlarged prostate or erectile dysfunction as there medicine may lower your blood pressure, possible upon standing.

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Ask your doctor if you have any questions about why PRILIGY has been prescribed for you. This medicine is available only with a doctor’s prescription. Before you take PRILIGY When you must not use it: Do not take PRILIGY if you are allergic to: • Any medicine containing dapoxetine • Any of the ingredients listed at the end of this leaflet. Symptoms of an allergic reaction may include rash, itching or hives on the skin, shortness of breath, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body. • If you are taking a MAOIs (monoamine oxidase inhibitors) used to treat depression, or have taken a MAOIs within the last 14 days.

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• If you are taking thioridazine used to treat schizophrenia, or have taken thioridazine within the last 14 days. Do not take PRILIGY if you have heart problems, such as heart failure or problems with the heart rhythm. Do not take PRILGIY if you have moderate to severe liver problems Do not take PRILIGY if you are under 18 years of age, or over 65 years of age. Safety and effectiveness in patients under 18 years or over 65 years have not been established. Safety and effectiveness in women have priligy 30 mg 6 tablet not been established. • Anti-inflammatory medicines such as ibuprofen (Nurofen®) or aspirin. These medicines may be affected by PRILIGY or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines. Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine. Taking PRILIGY Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet. If you do not understand the instructions on the box, ask your doctor or pharmacist for help. When and how much to take Always take PRILIGY exactly as your doctor has told you.

• Pregnant women and children should not take Priligy 15 mg due to lack of safety data.
• Priligy 15 mg is usually prescribed as part of a comprehensive treatment plan for early ejaculation.
• Combining Priligy 15 mg with other medications requires medical supervision to avoid interactions.

You must check with your doctor if you are not sure.

Do not take PRILIGY more than once every 24 hours.

• Priligy 15 mg is a fast-acting medication, usually effective within 1-3 hours of ingestion.
• It is not suitable for men with heart problems, liver issues, or those allergic to dapoxetine.
• Store Priligy 15 mg in a cool, dry place away from children and pets.

The usual dose is 30mg, taken when you need it about 1 to 3 hours before sexual activity. Your doctor may increase the dose to 60 mg. How to take it Swallow the tablet with at least one full glass of water. PRILIGY may be taken with or without food.

What is Premature Ejaculation

Do not take PRILIGY after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal. If you are not sure whether you should start taking this medicine, talk to your doctor. Before you startto use it: Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. Tell your doctor if you have not been diagnosed with premature ejaculation. If you forgot to take it As PRILIGY is only taken when needed, it is not a problem if you forget to take it. If you take too much (overdose): If you think you or anybody else has taken too much PRILIGY, contact your doctor, pharmacist or the Poisons Information Centre who will advise you what to do.

You can contact the Poisons Information Centre by dialling: • Australia: 13 11 26 • New Zealand: 0800 POISON or 0800 764 766. While you are taking PRILIGY Things you must do: If you are about to start on any new medicine, remind your doctor and pharmacist that you are taking PRILIGY.

• The medication is taken orally, usually in a single dose before sexual activity, not as a daily pill.
• Some men may experience transient side effects that resolve with continued use or dose adjustment.
• Always follow recommended guidelines for Priligy 15 mg to ensure safety and efficacy.

Tell any other doctors and pharmacists who are treating you that you are taking PRILIGY. If you are about to be started on any new medicines, tell your doctor or pharmacist that you are taking PRILIGY.

Priligy (Dapoxetine) 60mg - 3 Tablets

Effect of dapoxetine on ejaculatory performance and related brain neuronal activity in rapid ejaculator rats. Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. Dapoxetine for the treatment of men with premature ejaculation (PE): dose-finding analysis. J Sex Med 2010;7:256-68. J Sex Med 2011;8:524-39.

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Editorial comment on: Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: integrated analyses of two phase 3 dapoxetine trials. Dapoxetine treatment in patients with lifelong premature ejaculation: the reasons of a "Waterloo". Results from a Prospective Observational Study of Men with Premature Ejaculation Treated with Dapoxetine or Alternative Care: The paper reveals that premature ejaculation (PE) involves a complex interplay of serotonergic pathways and neurobiology, with serotonin primarily exerting inhibitory control. Somatic and autonomic pathways combine to coordinate ejaculation, influenced by factors like 5-HT 1A and 5-HT 2C receptor activity.

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In integrated clinical trials, dapoxetine significantly increased the geometric mean IELT from 0.8 to 2.0 and 2.3 minutes for 30 mg and 60 mg doses, respectively, compared to 1.3 minutes for placebo. This demonstrates dapoxetine’s effectiveness in managing premature ejaculation symptoms. Dapoxetine exhibits a short half-life of approximately 1.3 to 1.42 hours, allowing for rapid absorption and minimal drug accumulation. This profile makes it suitable for on-demand treatment of premature ejaculation, contrasting with longer-acting SSRIs. Adverse events for dapoxetine were reported in 56.1% of patients, primarily mild to moderate, including nausea (17.3%) and dizziness (9.4%). Be sure to keep all your doctor’s appointments so your progress can be checked. Priligy can make you faint or make your blood pressure drop when you stand up. To help lower the chance of this happening: • Take Priligy with at least one full glass of water. • Do not take Priligy if you are dehydrated (you do not have enough water in your body). • This can happen if: - You have not had anything to drink in the past 4 to 6 hours - You have been sweating for a long time - You have an illness where you have a high temperature, diarrhoea or being sick. • If you feel like you might faint (such as feeling sick, feeling dizzy, light headed, confused, sweaty or an abnormal heart beat), or feel light headed when you stand up, immediately lie down so your head is lower than the rest of your body or sit down with your head between your knees until you feel better. This will stop you from falling and hurting yourself if you do faint. • Do not stand up quickly after you have been sitting or lying down for a long time.

• Do not drive or use any tools or machines if you feel faint when taking this medicine. • Tell your doctor if you faint when taking this medicine. Things you must not do: Do not take PRILIGY to treat any other complaints unless your doctor tells you to. Do not give your medicines to anyone else, even if they have the same condition as you.

What is Generic Priligy composed of?

Discontinuation often occurred at higher doses, highlighting the importance of monitoring patient tolerance. The study indicates that dapoxetine is comparably effective in both lifelong and acquired PE, improving patient-reported outcomes significantly. However, patient adherence to treatment remains a challenge, with 30.4% of subjects discontinuing participation in trials. PRILIGY® Tablets dapoxetinehydrochloride Consumer Medicine Information What is in this leaflet This leaflet answers some common questions about PRILIGY tablets. It does not contain all the available information.

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It does not take the place of talking to your doctor or pharmacist. Your doctor has weighed the risks of you being given PRILIGY against the benefits this medicine is expected to have for you. If you have any concerns about taking PRILIGY ask your doctor. Keep this leaflet while you are taking PRILIGY. You may need to read it again.

Active Ingredient:

What PRILIGY is used for PRILIGY is a treatment for men 18 to 64 years old with frequent premature ejaculation (PE), which troubles the man and affects the relationship with his sexual partner. PE is a common sexual disorder in which ejaculation happens with minimal sexual stimulation before, on, or shortly after penetration, and before the man wishes it. PRILIGY, containing the active ingredient dapoxetine, is a type of drug called a selective serotonin reuptake inhibitor (SSRI) and belongs to a group of drugs known as other urologicals. PRILIGY increases your time to ejaculation and can improve your control over ejaculation and reduce your distress over how fast you ejaculate. This may improve your satisfaction with sexual intercourse. Avoid alcohol when taking PRILIGY The effects of alcohol such as feeling dizzy, sleepy and having slow reactions, may be increased if taken with PRILIGY.

• Consult your healthcare provider if you experience persistent side effects or if the medication is not effective.
• Priligy 15 mg is not intended for use as a cure but as a treatment for specific sexual health issues.
• Proper lifestyle changes, including stress management and healthy habits, can enhance treatment results.